Salvage therapy with high-dose cytarabine and mitoxantrone in combination with all-trans retinoic acid and gemtuzumab ozogamicin in acute myeloid leukemia refractory to first induction therapy
Identifieur interne : 000096 ( Main/Exploration ); précédent : 000095; suivant : 000097Salvage therapy with high-dose cytarabine and mitoxantrone in combination with all-trans retinoic acid and gemtuzumab ozogamicin in acute myeloid leukemia refractory to first induction therapy
Auteurs : Marie-Luise Hütter-Krönke [Allemagne] ; Axel Benner [Allemagne] ; Konstanze Döhner [Allemagne] ; Jürgen Krauter [Allemagne] ; Daniela Weber [Allemagne] ; Margit Moessner [Allemagne] ; Claus-Henning Köhne [Allemagne] ; Heinz A. Horst [Allemagne] ; Ingo G. H. Schmidt-Wolf [Allemagne] ; Mathias Rummel [Allemagne] ; Katharina Götze [Allemagne] ; Elisabeth Koller [Autriche] ; Andreas L. Petzer [Autriche] ; Hans Salwender [Allemagne] ; Walter Fiedler [Allemagne] ; Heinz Kirchen [Allemagne] ; Detlef Haase [Allemagne] ; Stephan Kremers [Allemagne] ; Matthias Theobald [Allemagne] ; Axel C. Matzdorff [Allemagne] ; Arnold Ganser [Allemagne] ; Hartmut Döhner [Allemagne] ; Richard F. Schlenk [Allemagne]Source :
- Haematologica [ 0390-6078 ] ; 2016.
Abstract
Outcome of patients with primary refractory acute myeloid leukemia remains unsatisfactory. We conducted a prospective phase II clinical trial with gemtuzumab ozogamicin (3 mg/m2 intravenously on day 1), all-
Url:
DOI: 10.3324/haematol.2015.141622
PubMed: 27036160
PubMed Central: 5004463
Affiliations:
- Allemagne, Autriche
- Bade-Wurtemberg, Bavière, District de Haute-Bavière, District de Karlsruhe, Hambourg, Sarre (Land), Vienne (Autriche)
- Hambourg, Heidelberg, Munich, Sarrebruck, Vienne (Autriche)
- Université Louis-et-Maximilien de Munich
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Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School</wicri:regionArea><wicri:noRegion>Hannover Medical School</wicri:noRegion><wicri:noRegion>Hannover Medical School</wicri:noRegion><wicri:noRegion>Hannover Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Weber, Daniela" sort="Weber, Daniela" uniqKey="Weber D" first="Daniela" last="Weber">Daniela Weber</name><affiliation wicri:level="1"><nlm:aff id="af1-1010839">Department of Internal Medicine III, University Hospital Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine III, University Hospital Ulm</wicri:regionArea><wicri:noRegion>University Hospital Ulm</wicri:noRegion><wicri:noRegion>University Hospital Ulm</wicri:noRegion><wicri:noRegion>University Hospital Ulm</wicri:noRegion></affiliation></author><author><name sortKey="Moessner, Margit" sort="Moessner, Margit" uniqKey="Moessner M" first="Margit" last="Moessner">Margit 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Oldenburg</wicri:noRegion><wicri:noRegion>Klinikum Oldenburg</wicri:noRegion></affiliation></author><author><name sortKey="Horst, Heinz A" sort="Horst, Heinz A" uniqKey="Horst H" first="Heinz A." last="Horst">Heinz A. 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Ulm</wicri:noRegion><wicri:noRegion>University Hospital Ulm</wicri:noRegion></affiliation></author><author><name sortKey="Benner, Axel" sort="Benner, Axel" uniqKey="Benner A" first="Axel" last="Benner">Axel Benner</name><affiliation wicri:level="3"><nlm:aff id="af2-1010839">Division of Biostatistics, German Cancer Research Center, Heidelberg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Division of Biostatistics, German Cancer Research Center, Heidelberg</wicri:regionArea><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Karlsruhe</region><settlement type="city">Heidelberg</settlement></placeName></affiliation></author><author><name sortKey="Dohner, Konstanze" sort="Dohner, Konstanze" uniqKey="Dohner K" first="Konstanze" last="Döhner">Konstanze Döhner</name><affiliation wicri:level="1"><nlm:aff id="af1-1010839">Department of Internal Medicine III, University Hospital Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine III, University Hospital Ulm</wicri:regionArea><wicri:noRegion>University Hospital Ulm</wicri:noRegion><wicri:noRegion>University Hospital Ulm</wicri:noRegion><wicri:noRegion>University Hospital Ulm</wicri:noRegion></affiliation></author><author><name sortKey="Krauter, Jurgen" sort="Krauter, Jurgen" uniqKey="Krauter J" first="Jürgen" last="Krauter">Jürgen Krauter</name><affiliation wicri:level="1"><nlm:aff id="af3-1010839">Department of Oncology and Hematology, Klinikum Braunschweig, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Oncology and Hematology, Klinikum Braunschweig</wicri:regionArea><wicri:noRegion>Klinikum Braunschweig</wicri:noRegion><wicri:noRegion>Klinikum Braunschweig</wicri:noRegion><wicri:noRegion>Klinikum Braunschweig</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af4-1010839">Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School</wicri:regionArea><wicri:noRegion>Hannover Medical School</wicri:noRegion><wicri:noRegion>Hannover Medical School</wicri:noRegion><wicri:noRegion>Hannover Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Weber, Daniela" sort="Weber, Daniela" uniqKey="Weber D" first="Daniela" last="Weber">Daniela Weber</name><affiliation wicri:level="1"><nlm:aff id="af1-1010839">Department of Internal Medicine III, University Hospital Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine III, University Hospital Ulm</wicri:regionArea><wicri:noRegion>University Hospital Ulm</wicri:noRegion><wicri:noRegion>University Hospital Ulm</wicri:noRegion><wicri:noRegion>University Hospital Ulm</wicri:noRegion></affiliation></author><author><name sortKey="Moessner, Margit" sort="Moessner, Margit" uniqKey="Moessner M" first="Margit" last="Moessner">Margit Moessner</name><affiliation wicri:level="1"><nlm:aff id="af1-1010839">Department of Internal Medicine III, University Hospital Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine III, University Hospital Ulm</wicri:regionArea><wicri:noRegion>University Hospital Ulm</wicri:noRegion><wicri:noRegion>University Hospital Ulm</wicri:noRegion><wicri:noRegion>University Hospital Ulm</wicri:noRegion></affiliation></author><author><name sortKey="Kohne, Claus Henning" sort="Kohne, Claus Henning" uniqKey="Kohne C" first="Claus-Henning" last="Köhne">Claus-Henning Köhne</name><affiliation wicri:level="1"><nlm:aff id="af5-1010839">Department of Oncology and Hematology, Klinikum Oldenburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Oncology and Hematology, Klinikum Oldenburg</wicri:regionArea><wicri:noRegion>Klinikum Oldenburg</wicri:noRegion><wicri:noRegion>Klinikum Oldenburg</wicri:noRegion><wicri:noRegion>Klinikum Oldenburg</wicri:noRegion></affiliation></author><author><name sortKey="Horst, Heinz A" sort="Horst, Heinz A" uniqKey="Horst H" first="Heinz A." last="Horst">Heinz A. Horst</name><affiliation wicri:level="1"><nlm:aff id="af6-1010839">Department of Internal Medicine II, University Hospital Schleswig-Holstein Campus Kiel, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine II, University Hospital Schleswig-Holstein Campus Kiel</wicri:regionArea><wicri:noRegion>University Hospital Schleswig-Holstein Campus Kiel</wicri:noRegion><wicri:noRegion>University Hospital Schleswig-Holstein Campus Kiel</wicri:noRegion><wicri:noRegion>University Hospital Schleswig-Holstein Campus Kiel</wicri:noRegion></affiliation></author><author><name sortKey="Schmidt Wolf, Ingo G H" sort="Schmidt Wolf, Ingo G H" uniqKey="Schmidt Wolf I" first="Ingo G. H." last="Schmidt-Wolf">Ingo G. H. Schmidt-Wolf</name><affiliation wicri:level="1"><nlm:aff id="af7-1010839">Department of Internal Medicine III, CIO, University Hospital of Bonn, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine III, CIO, University Hospital of Bonn</wicri:regionArea><wicri:noRegion>University Hospital of Bonn</wicri:noRegion><wicri:noRegion>University Hospital of Bonn</wicri:noRegion><wicri:noRegion>University Hospital of Bonn</wicri:noRegion></affiliation></author><author><name sortKey="Rummel, Mathias" sort="Rummel, Mathias" uniqKey="Rummel M" first="Mathias" last="Rummel">Mathias Rummel</name><affiliation wicri:level="1"><nlm:aff id="af8-1010839">Department of Hematology/Oncology, University-hospital Giessen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology/Oncology, University-hospital Giessen</wicri:regionArea><wicri:noRegion>University-hospital Giessen</wicri:noRegion><wicri:noRegion>University-hospital Giessen</wicri:noRegion><wicri:noRegion>University-hospital Giessen</wicri:noRegion></affiliation></author><author><name sortKey="Gotze, Katharina" sort="Gotze, Katharina" uniqKey="Gotze K" first="Katharina" last="Götze">Katharina Götze</name><affiliation wicri:level="4"><nlm:aff id="af9-1010839">Department of Internal Medicine III, Technical University of Munich, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine III, Technical University of Munich</wicri:regionArea><placeName><settlement type="city">Munich</settlement><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region></placeName><orgName type="university">Université Louis-et-Maximilien de Munich</orgName></affiliation></author><author><name sortKey="Koller, Elisabeth" sort="Koller, Elisabeth" uniqKey="Koller E" first="Elisabeth" last="Koller">Elisabeth Koller</name><affiliation wicri:level="3"><nlm:aff id="af10-1010839">Department of Hematology/Oncology, Hanuschkrankenhaus, Wien, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Hematology/Oncology, Hanuschkrankenhaus, Wien</wicri:regionArea><placeName><settlement type="city">Vienne (Autriche)</settlement><region nuts="2" type="province">Vienne (Autriche)</region></placeName></affiliation></author><author><name sortKey="Petzer, Andreas L" sort="Petzer, Andreas L" uniqKey="Petzer A" first="Andreas L." last="Petzer">Andreas L. Petzer</name><affiliation wicri:level="1"><nlm:aff id="af11-1010839">Department of Medical Oncology and Hematology, Krankenhaus der Barmherzigen Schwestern, Linz, Austria</nlm:aff><country xml:lang="fr">Autriche</country><wicri:regionArea>Department of Medical Oncology and Hematology, Krankenhaus der Barmherzigen Schwestern, Linz</wicri:regionArea><wicri:noRegion>Linz</wicri:noRegion></affiliation></author><author><name sortKey="Salwender, Hans" sort="Salwender, Hans" uniqKey="Salwender H" first="Hans" last="Salwender">Hans Salwender</name><affiliation wicri:level="3"><nlm:aff id="af12-1010839">Department of Hematology/Oncology, Asklepios Klinik Altona, Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology/Oncology, Asklepios Klinik Altona, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Fiedler, Walter" sort="Fiedler, Walter" uniqKey="Fiedler W" first="Walter" last="Fiedler">Walter Fiedler</name><affiliation wicri:level="3"><nlm:aff id="af13-1010839">Department of Internal Medicine II, University Medical Center Hamburg-Eppendorf, Hamburg, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine II, University Medical Center Hamburg-Eppendorf, Hamburg</wicri:regionArea><placeName><settlement type="city">Hambourg</settlement><region type="land" nuts="2">Hambourg</region></placeName></affiliation></author><author><name sortKey="Kirchen, Heinz" sort="Kirchen, Heinz" uniqKey="Kirchen H" first="Heinz" last="Kirchen">Heinz Kirchen</name><affiliation wicri:level="1"><nlm:aff id="af14-1010839">Department of Hematology/Oncology, Krankenhaus der Barmherzigen Brüder, Trier, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology/Oncology, Krankenhaus der Barmherzigen Brüder, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Haase, Detlef" sort="Haase, Detlef" uniqKey="Haase D" first="Detlef" last="Haase">Detlef Haase</name><affiliation wicri:level="1"><nlm:aff id="af15-1010839">Department of Hematology and Oncology, Georg-August-University Hospital of Göttingen, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology and Oncology, Georg-August-University Hospital of Göttingen</wicri:regionArea><wicri:noRegion>Georg-August-University Hospital of Göttingen</wicri:noRegion><wicri:noRegion>Georg-August-University Hospital of Göttingen</wicri:noRegion><wicri:noRegion>Georg-August-University Hospital of Göttingen</wicri:noRegion></affiliation></author><author><name sortKey="Kremers, Stephan" sort="Kremers, Stephan" uniqKey="Kremers S" first="Stephan" last="Kremers">Stephan Kremers</name><affiliation wicri:level="1"><nlm:aff id="af16-1010839">Department of Hematology/Oncology, Caritas-Krankenhaus, Lebach, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology/Oncology, Caritas-Krankenhaus, Lebach</wicri:regionArea><wicri:noRegion>Lebach</wicri:noRegion><wicri:noRegion>Lebach</wicri:noRegion><wicri:noRegion>Lebach</wicri:noRegion></affiliation></author><author><name sortKey="Theobald, Matthias" sort="Theobald, Matthias" uniqKey="Theobald M" first="Matthias" last="Theobald">Matthias Theobald</name><affiliation wicri:level="1"><nlm:aff id="af17-1010839">Department of Medicine III, Johannes Gutenberg-University Mainz, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Medicine III, Johannes Gutenberg-University Mainz</wicri:regionArea><wicri:noRegion>Johannes Gutenberg-University Mainz</wicri:noRegion><wicri:noRegion>Johannes Gutenberg-University Mainz</wicri:noRegion><wicri:noRegion>Johannes Gutenberg-University Mainz</wicri:noRegion></affiliation></author><author><name sortKey="Matzdorff, Axel C" sort="Matzdorff, Axel C" uniqKey="Matzdorff A" first="Axel C." last="Matzdorff">Axel C. Matzdorff</name><affiliation wicri:level="3"><nlm:aff id="af18-1010839">Department of Hematology/Oncology, Caritas-Krankenhaus, Saarbrücken, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology/Oncology, Caritas-Krankenhaus, Saarbrücken</wicri:regionArea><placeName><region type="land" nuts="2">Sarre (Land)</region><settlement type="city">Sarrebruck</settlement></placeName></affiliation></author><author><name sortKey="Ganser, Arnold" sort="Ganser, Arnold" uniqKey="Ganser A" first="Arnold" last="Ganser">Arnold Ganser</name><affiliation wicri:level="1"><nlm:aff id="af4-1010839">Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School</wicri:regionArea><wicri:noRegion>Hannover Medical School</wicri:noRegion><wicri:noRegion>Hannover Medical School</wicri:noRegion><wicri:noRegion>Hannover Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Dohner, Hartmut" sort="Dohner, Hartmut" uniqKey="Dohner H" first="Hartmut" last="Döhner">Hartmut Döhner</name><affiliation wicri:level="1"><nlm:aff id="af1-1010839">Department of Internal Medicine III, University Hospital Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine III, University Hospital Ulm</wicri:regionArea><wicri:noRegion>University Hospital Ulm</wicri:noRegion><wicri:noRegion>University Hospital Ulm</wicri:noRegion><wicri:noRegion>University Hospital Ulm</wicri:noRegion></affiliation></author><author><name sortKey="Schlenk, Richard F" sort="Schlenk, Richard F" uniqKey="Schlenk R" first="Richard F." last="Schlenk">Richard F. Schlenk</name><affiliation wicri:level="1"><nlm:aff id="af1-1010839">Department of Internal Medicine III, University Hospital Ulm, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine III, University Hospital Ulm</wicri:regionArea><wicri:noRegion>University Hospital Ulm</wicri:noRegion><wicri:noRegion>University Hospital Ulm</wicri:noRegion><wicri:noRegion>University Hospital Ulm</wicri:noRegion></affiliation></author></analytic><series><title level="j">Haematologica</title><idno type="ISSN">0390-6078</idno><idno type="eISSN">1592-8721</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Outcome of patients with primary refractory acute myeloid leukemia remains unsatisfactory. We conducted a prospective phase II clinical trial with gemtuzumab ozogamicin (3 mg/m<sup>2</sup> intravenously on day 1), all-<italic>trans</italic> retinoic acid (45 mg/m<sup>2</sup> orally on days 4–6 and 15 mg/m<sup>2</sup> orally on days 7–28), high-dose cytarabine (3 g/m<sup>2</sup>/12 h intravenously on days 1–3) and mitoxantrone (12 mg/m<sup>2</sup> intravenously on days 2–3) in 93 patients aged 18–60 years refractory to one cycle of induction therapy. Primary end point of the study was response to therapy; secondary end points included evaluation of toxicities, in particular, rate of sinusoidal obstruction syndrome after allogeneic hematopoietic cell transplantation. Complete remission or complete remission with incomplete blood count recovery was achieved in 47 (51%) and partial remission in 10 (11%) patients resulting in an overall response rate of 61.5%; 33 (35.5%) patients had refractory disease and 3 patients (3%) died. Allogeneic hematopoietic cell transplantation was performed in 71 (76%) patients; 6 of the 71 (8.5%) patients developed moderate or severe sinusoidal obstruction syndrome after transplantation. Four-year overall survival rate was 32% (95% confidence interval 24%-43%). Patients responding to salvage therapy and undergoing allogeneic hematopoietic cell transplantation (n=51) had a 4-year survival rate of 49% (95% confidence intervaI 37%-64%). Patients with fms-like tyrosine kinase internal tandem duplication positive acute myeloid leukemia had a poor outcome despite transplantation. In conclusion, the described regimen is an effective and tolerable salvage therapy for patients who are primary refractory to one cycle of conventional intensive induction therapy. (<italic><ext-link ext-link-type="uri" xlink:href="clinicaltrials.gov">clinicaltrials.gov</ext-link> identifier: 00143975</italic>)</p></div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Autriche</li></country><region><li>Bade-Wurtemberg</li><li>Bavière</li><li>District de Haute-Bavière</li><li>District de Karlsruhe</li><li>Hambourg</li><li>Sarre (Land)</li><li>Vienne (Autriche)</li></region><settlement><li>Hambourg</li><li>Heidelberg</li><li>Munich</li><li>Sarrebruck</li><li>Vienne (Autriche)</li></settlement><orgName><li>Université Louis-et-Maximilien de Munich</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Hutter Kronke, Marie Luise" sort="Hutter Kronke, Marie Luise" uniqKey="Hutter Kronke M" first="Marie-Luise" last="Hütter-Krönke">Marie-Luise Hütter-Krönke</name></noRegion><name sortKey="Benner, Axel" sort="Benner, Axel" uniqKey="Benner A" first="Axel" last="Benner">Axel Benner</name><name sortKey="Dohner, Hartmut" sort="Dohner, Hartmut" uniqKey="Dohner H" first="Hartmut" last="Döhner">Hartmut Döhner</name><name sortKey="Dohner, Konstanze" sort="Dohner, Konstanze" uniqKey="Dohner K" first="Konstanze" last="Döhner">Konstanze Döhner</name><name sortKey="Fiedler, Walter" sort="Fiedler, Walter" uniqKey="Fiedler W" first="Walter" last="Fiedler">Walter Fiedler</name><name sortKey="Ganser, Arnold" sort="Ganser, Arnold" uniqKey="Ganser A" first="Arnold" last="Ganser">Arnold Ganser</name><name sortKey="Gotze, Katharina" sort="Gotze, Katharina" uniqKey="Gotze K" first="Katharina" last="Götze">Katharina Götze</name><name sortKey="Haase, Detlef" sort="Haase, Detlef" uniqKey="Haase D" first="Detlef" last="Haase">Detlef Haase</name><name sortKey="Horst, Heinz A" sort="Horst, Heinz A" uniqKey="Horst H" first="Heinz A." last="Horst">Heinz A. Horst</name><name sortKey="Kirchen, Heinz" sort="Kirchen, Heinz" uniqKey="Kirchen H" first="Heinz" last="Kirchen">Heinz Kirchen</name><name sortKey="Kohne, Claus Henning" sort="Kohne, Claus Henning" uniqKey="Kohne C" first="Claus-Henning" last="Köhne">Claus-Henning Köhne</name><name sortKey="Krauter, Jurgen" sort="Krauter, Jurgen" uniqKey="Krauter J" first="Jürgen" last="Krauter">Jürgen Krauter</name><name sortKey="Krauter, Jurgen" sort="Krauter, Jurgen" uniqKey="Krauter J" first="Jürgen" last="Krauter">Jürgen Krauter</name><name sortKey="Kremers, Stephan" sort="Kremers, Stephan" uniqKey="Kremers S" first="Stephan" last="Kremers">Stephan Kremers</name><name sortKey="Matzdorff, Axel C" sort="Matzdorff, Axel C" uniqKey="Matzdorff A" first="Axel C." last="Matzdorff">Axel C. Matzdorff</name><name sortKey="Moessner, Margit" sort="Moessner, Margit" uniqKey="Moessner M" first="Margit" last="Moessner">Margit Moessner</name><name sortKey="Rummel, Mathias" sort="Rummel, Mathias" uniqKey="Rummel M" first="Mathias" last="Rummel">Mathias Rummel</name><name sortKey="Salwender, Hans" sort="Salwender, Hans" uniqKey="Salwender H" first="Hans" last="Salwender">Hans Salwender</name><name sortKey="Schlenk, Richard F" sort="Schlenk, Richard F" uniqKey="Schlenk R" first="Richard F." last="Schlenk">Richard F. Schlenk</name><name sortKey="Schmidt Wolf, Ingo G H" sort="Schmidt Wolf, Ingo G H" uniqKey="Schmidt Wolf I" first="Ingo G. H." last="Schmidt-Wolf">Ingo G. H. Schmidt-Wolf</name><name sortKey="Theobald, Matthias" sort="Theobald, Matthias" uniqKey="Theobald M" first="Matthias" last="Theobald">Matthias Theobald</name><name sortKey="Weber, Daniela" sort="Weber, Daniela" uniqKey="Weber D" first="Daniela" last="Weber">Daniela Weber</name></country><country name="Autriche"><region name="Vienne (Autriche)"><name sortKey="Koller, Elisabeth" sort="Koller, Elisabeth" uniqKey="Koller E" first="Elisabeth" last="Koller">Elisabeth Koller</name></region><name sortKey="Petzer, Andreas L" sort="Petzer, Andreas L" uniqKey="Petzer A" first="Andreas L." last="Petzer">Andreas L. Petzer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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